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Compounds

Cat No. Product Name Synonyms Targets
T13177L Tocainide Sodium Channel
Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.
T4S1876 3-Deoxyaconitine Sodium Channel
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele...
T5850 Benzamil Benzamil (hydrochloride) Na+/Ca2+ Exchanger , Sodium Channel
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.
T4490 PF-01247324 Sodium Channel
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
T12786 RY785 Potassium Channel
RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.
T16514 PF 04531083 Others , Sodium Channel
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.
TQ0011 PF-06869206 Sodium Channel
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
T15174 DSP-2230 Sodium Channel
DSP-2230 is a selective blocker of Nav1.7/Nav1.8.
T5324 BI 01383298 Sodium Channel
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
TQ0014 GNE-131 Sodium Channel
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
T37688 Cyfluthrin Reactive Oxygen Species , Sodium Channel
Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.
T23070 Nisoxetine hydrochloride Sodium Channel , Monoamine Transporter , Norepinephrine
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor
T19644 Benzonatate Sodium Channel
Benzonatate is an antagonist of sodium channel protein.
T8581 Flecainide hydrochloride Others
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.
T0924 Benzocaine Others , MRP , Sodium Channel
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
T9683 VX-150 Sodium Channel
VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).
T1787 Levobupivacaine Sodium Channel
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...
T9685 DS-1971a Sodium Channel
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
T0364 Dibucaine Cinchocaine CaMK , Sodium Channel , AChR
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.
T12181 NaV1.7 inhibitor-1 Sodium Channel
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
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